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Additionally, attempting to define the kinetics of changes in gene expression by sequential sampling is pragmatically unrealistic.
We describe a novel method to directly assay CPP-mediated delivery of peptide cargo into the cytosol, and use this method to define the kinetics of this process.
The Pitzer ion interaction model and the Freundlich non-equilibrium isotherms are utilized to define the kinetics of salt crystallization/dissolution.
In this study we define the kinetics of TF expression in the lung at the mRNA, protein and activity level.
Fractional power model (FP), pseudo first-order (PFO) and pseudo second-order (PSO) are common empirical models; however, their major drawback is that they may simply define the kinetics of adsorption at some restrictive situations (Haerifar and Azizian 2013).
While further experiments are required to define the kinetics of infiltration into the CNS, we conclude that adoptively transferred SCILs are competent to enter the demyelinated spinal cord.
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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.
Defining the kinetics of orexin signaling is fundamental for understanding normal neurobiology, especially in relation to variations in arousal and sleep/wake regulation.
Initial studies, aimed at defining the kinetics of PI3K/mTOR and canonical Smad signaling in pHLFs during TGF-β1-induced collagen deposition, revealed that Smad signaling was rapid and relatively short-lived with Smad2 phosphorylation peaking within the first hour and declining after 2 h (Fig. 1a).
We have defined the kinetics of neuron-specific BAF complex assembly in the formation of induced neurons from mouse embryonic stem cells, human fibroblasts, and normal mouse neural differentiation and, using proteomic analysis, found that this switch also includes the removal of SS18 and its replacement by CREST at mitotic exit.
Another important factors are temperature, which defines the kinetics of the process[21], as well as the way the substrates is exposed to the polyelectrolytes solutions, for example, by dipping or spray[22].
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