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There is a pressing need for methods to define the functional relevance of genetic alterations identified by next-generation sequencing of cancer specimens.
In order to define the functional relevance of expression of the 50 kDa P-cadherin variant in malignant melanoma, antisense P-cadherin cell clones were generated.
Subsequent biochemical assays define the functional relevance of these NMR-based observations.
The FANCC and SVOPL DMRs are not well studied, and further studies are needed to define the functional relevance of these methylation changes.
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Ultimately, placing cortical areas within the context of a particular neural network may be the key to defining the functional relevance of individual cortical areas.
Finally, to determine the functional relevance of haplotypes defined by SNP-420 and SNP-358, we performed transfection experiments using THP-1 human monocytes.
It is, therefore, proposed to first define the functional domain of interest and then select (combinations of) markers that indicate clinical relevance and for which a plausible hypothesis explaining how they could be related is available.
We define the functional (4.73).
Define the functional with (4.7).
Define the functional by (3.14).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com