Sentence examples for define the determinants that from inspiring English sources

We next made use of a panel of characterized Nef mutants to define the determinants that govern its effects on subcellular Lck distribution (Fig. 3).

To define the determinants within Vpu that are involved in NF-κB inhibition, we performed triple-alanine scan mutagenesis in the cytoplasmic domains of two HIV-1 (WITO, CH106) Vpus.

To better define the structural determinants that mediate the anti-adhesive functions of Trask, we generated a series of deletion mutants of Trask and expressed them in tet-inducible cell models to define the structural elements involved in cell adhesion signaling.

Pharmacokinetic/pharmacodynamic research models offer promising approaches to define the determinants of resistance selection and drug doses that optimize efficacy and reduce resistance selection.

Uncovering the determinants that define this specificity in polyspecific substrate recognition may provide the key to combating multidrug resistance.

Alanine-scanning was used to define the determinants of the interaction between the peptides and tRNALys3.

We have begun to define the determinants of epigenetic activity of the GFP-COP1 loci.

Therefore, attempts to better define the molecular determinants that drive breast cancer cell proliferation may help in defining potential therapeutic targets.

If so, the determinants that justify this approach (e.g., biology or pattern of relapse) must be defined.

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With the current study we have progressed toward defining the determinants of resistance by establishing that resistance and sensitivity to a prototypical hydroxamate HDACi can be modeled in DLBCL cell lines which express genes significantly associated with poor prognosis in DLBCL patients.