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Using this structure, we define the contribution of the 5'- and 3'-primer ends to Chk1 activation when replication is blocked and ongoing.
To define the contribution of the corneal epithelium in corneal topography in keratoconus and discuss the implications regarding combined topography-guided photorefractive keratectomy and corneal collagen crosslinking (CXL).
Each zone then has the option of its own actions, objectives and constraints, with the flexibility to define the contribution of each zone to achieve targets for pre-specified features (e.g. species or habitats).
This chapter will therefore define the contribution of emerging approaches and recent advances in the field of computational chemistry for translating the atomic-level understanding of complex biological phenomena into useful information to progress in molecular medicine.
More mechanism-based research at the homeostatic/reward/diet interface may enable diets to be manipulated with therapeutic benefit, or define the contribution of these interactions to susceptibility to diet-induced obesity.
Our long-term goal is to (1) further understand how neuroinflammatory processes injure synapses and neurons and disrupt circuits, (2) define the contribution of the COX-2/prostaglandin signaling pathways in this process, and (3) develop therapeutic strategies targeting injurious inflammatory processes in human neurological diseases.
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The total and partial density of state curves are used to define the contributions of the different bands.
Obviously, if a collaboration were to ensue, it would be essential to define the contributions of the different individuals.
To define the contributions of different serum Se proteins to the phenotype we analyzed the enzyme activity of Gpx3 in the serum of wild-type and TRα1+m mice with and without T3 treatment (Fig. 3B).
Herein, we have used A-1210477 and other selective BCL-2 family inhibitors to define the contributions of MCL-1, BCL-2 and BCL-XL in maintaining the survival of various NHL cell lines.
They require both high-throughput genotyping platforms and large samples sizes with thousands of subjects from multiple sources and time points to clearly define the contributions of common alleles associated with common complex diseases.
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