Sentence examples for define the best dose from inspiring English sources
Moreover, among the published trials, the dose for the metronomic chemotherapy is often arbitrarily chosen (e.g., the 'classic' fixed dose of 50 mg day−1 of CTX simply corresponds to a single tablet of the commercially available medicament) and no further efforts have been made to define the best dose.
Meanwhile, trough IM plasma levels could help physicians to define the best IM dose [ 8].
Additional studies using the TRG delivery system also will help define the best models, doses, and conditions to guide further development for eventual use in human immunization.
We first performed a maximally tolerated dose study to define the best conditioning procedures and then tested the effect of the determined sublethal conditions (20 mg/kg busulfan vs 2.25 Gy irradiation) on NSG mice.
Further research in this area should be directed to define the best cytotoxic agent for combination with gemcitabine, or altering the dose intensity or route of administration in advanced gall bladder cancer.
Further randomized studies are needed to define the best therapy for high-risk patients (inpatients, patients with active cancer or previous VTE), and the optimal dose and duration of treatment.
The primary study objectives were to evaluate sarilumab efficacy during the 12-week treatment period according to the Axial SpondyloArthritis international Society (ASAS 20 22 outcome measure in patients with AS, and to define the best dose/dosage regimen for further development.
The dose level with the best dose intensity for multiple courses was 150 μg m−2.
However, the question of the "best" dose model is of minor importance to the appropriateness of the cumulative dose concept.
Defining the best chemotherapy combination has remained a challenge.
