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A range of technical platforms are used preclinically to define responses to therapy, the most informative of which are adopted for use in patients.
Modern genome-wide approaches may offer a possible solution and are increasingly being used to unravel the molecular mechanisms that define responses to environmental stressors and to predict their adverse effects on critical biological pathways.
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Additional effort is required to define response to OBT-A and to establish optimal treatment duration.
Additional effort from the headache community is required to define response to treatment and to establish the optimal duration of prophylaxis with OBT-A.
These calculations were used to establish a cut-off value to define response to chemotherapy.
Changes in stroke volume (SV) were used to define response to volume challenge.
Changes in stroke volume were used to define response to volume challenge.
How to better monitor disease activity of SLE and LN separately to better define response to treatment, and to dissect ongoing immunologic activity from persistent kidney damage.
Another reason for the lack of association could be due to the use of the EULAR classification criteria to define response to treatment within this study, whereas in the original study patients were classified according to the ACR response criteria.
Future clinical trials could investigate the methods to define response to trabectedin and it could also be hypothesized to use the drug as maintenance therapy to positively impact the overall survival of patients with soft tissue sarcoma.
Although only the ReQuest™-GI sub-scale was used to define response to treatment, both sub-scales and the total score were used in exploring the potential of ReQuest™ to predict treatment outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com