This study was too small to define organism-specific metabolic responses, which will be useful for diagnosis, and it was not possible using available sensitive molecular techniques to distinguish causative pathogens from asymptomatic 'DNAemia'DNAemia
In contrast, Tang and colleagues [ 30] were unable to define organism-specific gene expression signatures (Gram positive versus Gram negative bacteria) in critically ill adults with sepsis.
These two opposing requirements ultimately lead to optimization of the epithelium turnover rate for a defined organism, allowing maintenance of tissue integrity and organ function with minimal stem cells and cell divisions required.
User defined organism and pathway subsets of the KEGG database at the time of analysis result in the online retrieval of a defined set of protein sequences via the KEGG API (API methods: list_organisms; list_pathways).
Porcine tissues were used because they are available in large amounts, while murine tissues were analyzed at a later stage to confirm the results in a genetically more defined organism.
PK/PD breakpoints represent the highest MIC for which the unbound plasma concentrations of the antimicrobial drug (following standard doses) are sufficient to achieve the PK/PD target against a defined organism and for which adequate clinical data support their use.
In this study, a subset of natural substances originating from defined organisms which are applied in personal care products is considered.
A patient in whom any of the defined organisms were cultured within 48 hours of ICU admission met the criteria for the composite measure of any resistant organism on admission.
A patient for whom any of the defined organisms were discovered in cultures taken after 48 hours in the ICU, and who was not infected/colonized with the specific organism on admission, met the criteria for the composite measure of ICU acquisition of any resistant organism.
Pathway-specific perturbational profiling and integrated systems approaches have previously been used in genetically defined organisms to identify genetic nodes of regulation underlying disease (Gagneur et al., 2013; Gat-Viks et al., 2013; Smith and Kruglyak, 2008; Zhang et al., 2013).
Of them, 26 protein entries were full length sequences found in defined organisms (table 1), 6 protein entries were shorter sequences lacking several residues (table 2), and 57 protein entries were protein fragments extracted from "uncultured soil bacteria" (Additional file 1: Table S1).
