In the last few years, WES has been instrumental in defining the culprit gene(s) for dozens of Mendelian diseases [ 15].
The progression of atherosclerosis in the native coronary arteries (defined if the culprit lesions reducing vessel diameter by at least 70% were located distally to anastomoses with the grafts or in the nonbypassed coronary arteries) was seen in 15 patients, including 4 cases without significant changes in the grafts.
The investigation must not show "prejudice in defining the possible culprits in the disaster or anticipation of any results of the investigation," Russia emphasised.
From the 1980s through the 1990s, Fraser, Arieff, and their colleagues first defined hyponatremia as the culprit in numerous deaths, seizures, and comas--particularly in women--after they have had routine surgeries.
The culprit lesion, defined as the segment with greatest plaque burden, was fixated in 4% formalin for 7 days and then decalcified in EDTA and embedded in paraffin.
Furthermore, cardiovascular risk factors, reperfusion times, medication, culprit vessel, thrombolysis in myocardial infarction (TIMI) flow grade before and after PPCI as well as LV function and volumes were assessed to define possible influencing factors of IMH (Table 1).
As Pax8 along with Pax5 and Pax2 define group II of the Pax family with over 95% protein homology in the common paired DNA binding domain, it is tempting to speculate that Pax5 or Pax2 are potential culprits.
When South Africa's president recently seemed to suggest that the HIV virus might not be the direct cause of AIDS, he left vaguely defined "environmental" causes as the culprit.
The coronary artery showing the culprit lesion was defined as infarct-related artery (IRA).
Culprit plaques were defined as lesions showing either plaque rupture or erosion with superimposed thrombus.
