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The exclusion criterion was the presence of a definable infection at the time of admission.
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Exclusion criteria were patients with a blood smear positive for malaria parasites or those with another definable source of infection on admission such as pneumonia or urinary tract infection.
Patients with a blood smear positive for malaria parasites or those with another definable source of infection on admission such as pneumonia or urinary tract infection were excluded from the study.
Infection was defined when clinical signs of systemic inflammatory response were present, determined by a definable source of infection (microbiology confirmed) and/or positive blood cultures.
Diarrhoea caused by a variety of definable pathogens (opportunistic infection) is also a common problem in human immunodeficiency virus (HIV -infected patients witHIV -infected <200 cells/μl or patients with advanCD4+human immunodeficounts virus (AIDS) [ 9].
Exclusion criteria were patients with a definable source of infection on admission.
Patients had a definable source of infection and/or positive blood cultures and received antibiotic treatment.
Patients were defined as having an infection when a clinically definable source of infection was present, as confirmed by microbiology tests and/or positive blood cultures.
In the present study, infection was defined when clinical signs of systemic inflammatory response were present, determined by a definable source of infection (microbiology confirmed) and/or positive blood cultures.
PTU-induced AAV was defined as follows: (a) the signs and symptoms of vasculitis were temporally related to using PTU, and regressed with its discontinuation; (b) serum ANCA was positive, especially in those with multi-antigenicity; and (c) medical conditions that mimicked vasculitis were excluded, especially infections and malignancies, and other definable types of vasculitis [ 17].
However, we designed our model to be based on risk factors present and definable on hospital admission, and so, a diagnosis of bacterial infection served as an appropriate surrogate.
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