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Burns and Goldstein state that "'multiple symptoms' is not a definable disease or illness".
The biologic significance of the outcome "symptom count" is unknown; also, "multiple symptoms" is not a definable disease or illness.
Vertigo and dizziness include both consequences of disease as well as definable disease entities such as benign paroxysmal positional vertigo, Meniere's disease, or vestibular migraine.
These mutations have been linked to various forms of epilepsy in humans, providing evidence that changes in VSSC function can give rise to clinically definable disease (Claes et al. 2001; Escayg et al. 2001; Meisler et al. 2002; Noebels 2002; Wallace et al. 2001).
The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification.
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This approach allowed us to examine known disease-tissue relationships and to predict newly definable disease-tissue associations.
Myeloid leukemia includes some of the most well understood malignancies in humans, but also rare and less definable diseases.
Whereas OA is the culmination of multivariate interactions between genetic, epigenetic, and environmental factors, extrinsic factors such as obesity, trauma, and joint loading patterns are known to heighten OA risk and to offer more definable targets for disease modification.
Exclusion criteria included a diagnosis of limited cutaneous SSc, eosinophilic fasciitis, eosinophilia myalgia syndrome, other overlap autoimmune syndromes, or concurrent diagnosis with another definable connective tissue disease, or a known history of any chronic infections.
It does, however, assert that there are distinct and definable stages of disease-modifying treatment, palliative care and end-of-life care that have different content but that may also overlap.
We did this in subjects who were located at three clinically definable points along the disease trajectory in Alzheimer's disease: healthy cognitively normal controls (CN), subjects with amnestic MCI (aMCI) and subjects with Alzheimer's disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com