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34 RERI is an estimate of excess or deficit risk that is attributable to the interaction between two exposures, in this case GRS and each one of the ConvRFs; it measures deviation from additivity of effects independently of the risk scale of the outcome.
The only significant associations (p < 0.05) with the broadly defined groups of anomalies was a deficit risk of abdominal wall defects in the high TTHM exposure category [odds ratio (OR) = 0.81; 95% confidence interval (CI), 0.68 0.95] and an excess risk of major cardiac defects in the medium (but not high) exposure category of total brominated THMs (OR = 1.12; 95% CI, 1.01 1.23) (Table 4).
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