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end{aligned} (6.10)We shall refer to the term (delta (f)) at the right hand side of the previous equation as to the Sobolev deficit of the function f.
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The deficit of the Crx function led to the failure of forming the photoreceptor outer segment (OS) and the inhibition of expressing OS-specific genes [ 27].
According to Executive Function (EF) models of ADHD an impulsive response style is linked to behavioural disinhibition and associated deficits of the executive function system.
The fact that up-regulation of the TFEB-driven gene network was demonstrated in lysosomal storage disorders and can be induced by lysosomal inhibitors suggests that deficits of the lysosomal function are reported through this gene network as well.
Though functional imaging has revolutionized the field of brain function mapping in the last 20 years, the necessity of a brain region for a putative function arguably the strongest test can only be established by showing a deficit when the function of the region is disrupted.
> A deficit of male function genes on the X chromosome may reflect a history of selection for demasculinization (Parisi et al. 2003; Gupta et al. 2006; Sturgill et al. 2007).
Propagation of organisms with ambiguous proteomes could occur if the non-cognate amino acid were either close to selectively neutral or provided a net selective advantage that overcame any deficits in the function of individual proteins.
The mass gradually increased in size and often had a further clinical progression of deficit of motion and function of the digits.
In particular, TNF was found to inhibit the suppressive activity of CD4+CD25+ Treg cells, and anti-TNF therapy has been shown to restore the deficit of Treg suppressive function in patients with RA [ 18].
For example, Down syndrome is associated with a general deficit of cholinergic function, several motor disorders involve alterations of dopaminergic circuitry, and epilepsy may involve deficits in GABAergic function.
A deficit in the functioning of the hypothalamic-pituitary-adrenal axis in patients with FM might be responsible for the lower levels of the resilience in those patients; additionally, this deficit may exacerbate the symptoms as a consequence of the maladaptive response to stress that many of these patients exhibit [ 66].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com