With respect to small-animal imaging, however, there still seems to exist a marked deficit of validation studies demonstrating the quantitative accuracy of ASL, and reliable data are scarce [7, 13, 14].
The funnel plots searching for publication bias (supplementary data) did not reveal a deficit of small studies with negative results.
The funnel plots searching for publication bias did not reveal a deficit of small studies with negative results, suggesting that overall there was no publication bias.
The lack of objective research methodologies is a major deficit of the studies evaluating patients with spinal stenosis, and potentially, issues of mental overlay could render the results bias.
While the evidence of specific health benefits from "nature-assisted" therapy (for example nature hikes) is unclear due to a deficit of rigorous studies, the extant evidence suggests a therapeutic effect.
Another methodological deficit of this study was the low number of study participants, recruited from one single orthodontic practice.
A systematic review of previous studies of the built environment and childhood obesity identified inconsistencies in measurements of the built environment across studies and cross-sectional designs as major deficits of previous studies, and noted that these studies rarely studied both diet and physical activity (Papas et al. 2007).
The most apparent deficit of the original studies lies in their study design, which was generally based on a retrospective analysis of a single cohort.
Importantly, the retrospective design and small sample sizes are major deficits of those studies and result in limited significance of reported findings.
In conclusion, despite the deficits of reported studies, the available data suggest that patients on antiplatelet therapy may have a higher risk of mortality and morbidity after TBI, especially in cases of posttraumatic ICH.
