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The findings indicated that boys with ADHD exhibit an early perceptual deficit in selection of visual stimuli on the basis of color (red versus blue) as well as in later semantic stages of visual selective attention [ 7].
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Only when a TCR transgene was prematurely expressed at higher than normal levels in DP thymocytes was there a measurable deficit in positive selection, and even under these conditions there was a small decrease in positive selection compared even to the subtle Zap70 murdock mutation (Siggs et al., 2007).
The major limitation of our study is that the GPs were asked to identify only those patients who they suspected to have a cognitive deficit (see selection criteria in the "Methods" section), and only those patients who scored 24 or less were evaluated by the UVAs.
However, this is not what we observe (Fig. 3), and this cannot be attributed to a selection bias against phonological deficits in the control group (phonological tasks were not used at all in selection criteria).
The proportion of genetic variance is 60% in Selection I; 49% in Selection II; 51% in Selection III; 47% in Selection IV and 76% in Selection V.
Further experiments will be required to identify the exact ADAM17 substrates involved in Aire regulation and whether and the ADAM17 deficit in TECs leads to breaches in the regulation of negative selection in thymocytes and self-tolerance.
For the CAD gene, Fu and Li's D* and F* tests highlighted a deficit in rare mutations, which is usually the trademark of balancing selection [ 43].
To see if these mice suffered from a deficit in T cell suicide, the team first had to magnify the negative selection, which is normally a rare event.
The Treaty of Lisbon may go some way to resolving the deficit in creating greater democratic controls on the Commission, including enshrining the procedure of linking elections to the selection of the Commission president.
The projected deficit in 2016 is $550 million.
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