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Prenatally choline deficient animals yielded significantly fewer electrophysiological viable hippocampal slices than did animals from either of the other two treatment groups.
Crosses between TNFtg and IL-1 deficient mice yielded insight into IL-1-dependent elements and it was convincingly demonstrated that TNF drives inflammation.
Ndst2-deficient females yielded pups that thrived normally.
All of the 12 G6PD-deficient patients yielded similar results-with higher percentages of infected monocytes than were found in the 24 healthy donors (Figure 5).
In line with this rationale, preclinical investigations using selective iNOS inhibitors or iNOS-deficient mice yielded promising results [ 27, 28].
Explanted fetal thymic organ cultures (FTOCs) of Sox-4-deficient thymus yielded 10 50-fold 10 50-foldCD8 double-positive and single-positive cells than fewer of littermates [ 34].
However, these approaches are frequently deficient in the yield and the manufacturing processes of these approaches are complicated.
More than 135 studies focused on genetically modified immune deficient mice, which now yield more than 1200 publications and patents (Google Scholar, December 2014).
124 Nevertheless, when glucose/glycogen concentration is reduced due to fasting or low carbohydrate intake, or when resulting from insulin resistance for example, oxaloacetate yield becomes deficient.
Thermophilic ethanol producing strains are classically deficient in producing higher yields (theoretically >90%%) as well as in tolerating high level (typically >40 g/L) of ethanol and exhibit low ethanol tolerance (<2 %, v/v).
However, a comparison of wild-type and c-cbl-deficient BMMCs did not yield differences in Ag-triggered degranulation [ 83].
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