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No differences were observed in footpad measurements between PAR-1-deficient, PAR-2-deficient and PAR-3-deficient mice when compared with their control littermates (+/+ or +/-).
FA C18 2 n-6 is accumulated in PPAR α deficient mice when compared with wild-type mice.
A significant concentration-dependent increase in PARP cleavage was observed in MLH1-deficient cells when compared with MLH1-proficient comparators at nanomolar concentrations.
Our recent study confirmed the importance of TLR4 in the generation of proinflammatory cytokines crucial to the induction of mitochondrial oxidative stress; using real-time PCR and Western blot analysis, we found that TNF-α and iNOS were markedly downregulated in TLR4-deficient mice when compared with wild-type mice with EAU [4].
Coincidentally, more mRNA-derived individual sRNAs were found in P-deficient treatment when compared with those in P-sufficient treatment.
Intestinal inflammation is reduced in dextran sodium sulphate-treated IL-33-deficient mice when compared with control animals.
Importantly, recovery of locomotor function is facilitated in Fas-deficient mice when compared with Wt mice after SCI.
Overall, H3K27me3-marked genes tended to be expressed at lower levels in both control and Ezh2-deficient cells when compared with genes lacking H3K27me3 (supplementary material Fig. S8A).
The data (Fig. 5) clearly demonstrated higher cytotoxicity of NK cells derived from spleens of healthy ST2-deficient mice when compared with WT mice (p<0.01).
Similarly, markedly lower rates of bacteraemia were noted in virus/ S. pneumoniae-infected IL-27R-deficient mice when compared with WT mice (Fig 3F).
Anatomical and histological examinations did not reveal any abnormality in mFwe-deficient animals when compared with mFwe heterozygous or wild-type littermates (supplementary material Fig. S3B E).
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