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The results with the initial architectural design of the room show a very deficient ventilation at the patients site.
Although large droplets probably accounted for some cases in the Alaska Airlines outbreak (9 ), this outbreak was remarkable for its high attack rate (72%) and for deficient ventilation, which would increase transmission by aerosols but not by large droplets.
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Bronchopulmonary dysplasia (BPD) was first described in 1967 by Northway et al., who hypothesized that its pathogenesis stemmed from prolonged mechanical ventilation of the surfactant-deficient lung with high concentrations of inspired oxygen (hyperoxia) [ 1].
Indices of high-permeability pulmonary edema and lung inflammation induced by injurious ventilation were lower in Tpl2-deficient mice than in WT ones.
Representative photographs of hematoxylin-eosin-stained lung sections, ×200 magnification, from control wild-type and Tpl2-deficent mice and from wild-type and Tpl2-deficient mice subjected to high tidal volume ventilation for 210 min (n = 4 per group) and calculated lung injury score.
Hoetzel and colleagues [ 31] demonstrated that Egr-1-deficient mice did not sustain lung injury after ventilation, relative to wild-type mice.
Lung injury induced by high-tidal-volume ventilation was attenuated with PAI-1-deficient mice and pharmacologic inhibition of PAI-1 activity by low-dose unfractionated heparin and enoxaparin.
Although the differences were not statistically significant on univariable analysis, we observed that children who were vitamin D deficient at admission were more likely to require mechanical ventilation, inotropes, fluid boluses, have higher organ dysfunction scores and have prolonged duration of mechanical ventilation.
Arterial blood gas PaO2 from wild-type (WT, white boxes), and Tpl2-deficient mice (Tpl2-/-, gray boxes) subjected to mechanical ventilation with normal tidal volume (VT) for 240 min, or high VT for 210 min (n = 6 to 8 per group).
We measured lung injury parameters in response to ventilation in C57/BL6 (wild-type) mice and strains genetically deficient in MKK3 and JNK1.
Mice deficient in mmp8−/− were used for control and 8 hours mechanical ventilation conditions.
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