In addition, while Smad1/5 phosphorylation, downstream of BMPR2 occurs at the plasma membrane and is not affected by deficient endocytic trafficking, continuation of Smad signaling requires receptor internalization [ 55], which cannot occur efficiently due to impaired endocytic traffic caused by KDITSN [ 2, 19].
Yet, modification of adenoviral tropism, especially fiber gene engineering, can induce deficient intracellular trafficking of the viral particle, with a shift in subcellular localization resulting in extensive exocytosis.
This result indicates that the low amount of cell surface MOR-mcherry does not result from deficient receptor trafficking, but rather reflects the genuine distribution of the native receptor.
Mutant forms that are most likely to show increased total cellular α-Gal A activity in Fabry patients treated with AT1001 are physically unstable, prone to inefficient or aberrant folding, have deficient lysosomal trafficking, and/or show increased levels in cultured cells upon binding and stabilization by AT1001.
In 1939, the commission closed off the structurally deficient bridge to traffic, and began looking into ways to build a new bridge in the area.
In addition some of these protrusions are physiologically relevant since they may function in pinocytosis to compensate for deficient endocytic membrane traffic via caveolae and CCVs [ 19].
It was jerky and rocky, through dense traffic and deficient roads.
Virus is able to reach the central nervous system more quickly after vaginal infection in mice deficient in CXCL10, and trafficking of NK cells and HSV-specific CD8+ T-cells (but not CD4+ T-cells) to infected tissue is impaired in both CXCL9 and CXCL10-deficient mice [54].
These differences are likely due to the specific N996I mutation, which results in a less severe LQT2 phenotype than those caused by other trafficking-deficient mutations (Moss et al, 2002).
They cross plenty of dubious bridges on their way to work (156,000 of them are structurally deficient), sit in too many traffic jams, and deal with too many water main breaks.
One of America's many structurally deficient bridges, the Frederick Douglass Memorial is trafficked by over 70,000 cars traveling to and from the nation's capital.
