However, the expression changes of the remained 19 target genes had a positive correlation with their corresponding miRNAs, which might be the results of the interaction of different target genes.> -wrap-foot> Both fold change of miRNAs and relative change of target genes are the ratio of B-deficient to –sufficient leaves.
Our example of application was based on the comparisons of the root and leaf transcriptomes of the metal homeostasis mutant nas4x-1 [ 14] and wild type plants in response to sufficient and deficient Fe supply.
Most GmaPHO1 genes were expressed in roots and responded to Pi deficient or sufficient treatments in complex manners.
Conversely, using the Tet-inducible Npc1 mouse model, neuron-specific NPC1 in an otherwise NPC1-deficient animal was shown to be sufficient to prevent and halt local neurodegeneration, altering neurological signs in an animal with continued systemic disease progression (Fig. 2C) (Lopez et al., 2011; Lopez et al., 2012b).
In addition, the adoptive transfer of CYLD-deficient T cells into RAG1-deficient mice was sufficient to induce the inflammatory phenotype, underscoring that the abnormal response of T cells in CYLD-deficient mice was responsible for the occurrence of the inflammatory phenotype.
In fact, IL-13-producing lung ILC2 were upregulated following intranasal IL-25 or IL-33 administration, or during an ovalbumin-driven model of allergic asthma [ 24], and adoptive transfer of wildtype, but not IL-13-deficient, ILC2 was sufficient to restore IL-25-induced AHR to otherwise resistant IL-13-deficient mice.
To test this, male Sprague-Dawley rats were exposed to a choline chloride deficient (DEF), sufficient (CON), or supplemented (SUP) diet during embryonic days 12-17 and then returned to a control diet (1.1 g choline chloride/kg).
Contrary to wildtype mice, age- and light-induced stress in Cx3cr1 deficient animals are sufficient to induce CCL2 expression and CCR2+ monocyte recruitment to the subretinal space at a rate exceeding that of their clearance, and subretinal MPs accumulate.
When ESAs are administered to patients deficient or marginally sufficient in iron, the demands for iron for Hb production are likely to further deplete iron available for other essential metabolic processes The rise in plasma TNF-α and decrease in IL-4 levels may also be important as noted above.
In fact, an acute exposure of cultured hepatocytes to distinct lipid stimuli, for instance fatty acids or culturing in methionine and choline-deficient medium, was sufficient to induce autophagy [ 33].
Notably, adoptive transfer of wild-type Treg into CD81-deficient mice was sufficient to promote tumor growth and metastasis.
