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The overactivity, impulsiveness and deficient sustained attention of the SHR/NCrl strain are independent behaviors.
ADHD is characterized by age-inappropriate hyperactivity, impulsiveness, and deficient sustained attention [ 1].
Thus, overactivity does not account for this strain's impulsiveness and deficient sustained attention.
The best validated animal model of ADHD, the Spontaneously Hypertensive Rat (SHR), shows pronounced overactivity, impulsiveness, and deficient sustained attention.
Thus, overactivity does not account for impulsiveness and deficient sustained attention in either SHR/NCrl, or in WKY/NHsd rats.
These alterations bring about a different learning style resulting in increased behavioural variability, in addition to hyperactivity, impulsiveness, and deficient sustained attention.
Similar(45)
Eight of 14 secretion-deficient constructs sustained inserts in the C-terminal part of the passenger domain or the N-terminus of the β-domain (Fig. 1A).
TLR4-deficient mice sustained smaller infarctions and exhibited less inflammation compared to wild type mice after myocardial ischemia-reperfusion injury induced by 1 hour of coronary ligation followed by 24 hours of reperfusion [38].
Whereas the former efficiently entered the cell cycle reaching a level of 32% PCNA positive nuclei 36 hours post PH, UPF2 deleted hepatocytes were essentially deficient in sustaining liver regeneration as assayed by both Ki67 and PCNA staining.
Patients frequently become endotoxemic and febrile as well as BPI-deficient due to sustained neutropenia.
In response to the later questions, we did find that Plk3-deficient livers exhibit sustained UPR signaling following tunicamycin treatment, suggesting that they cannot resolve ER stress as efficiently.
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