Sentence examples for deficient specific from inspiring English sources

In our BAR-T cells, which are already p16 deficient, specific knockdown of the p53 pathway alone did not induce features of neoplastic transformation.

The anticipated finding in our experiments employing isoform-specific antibodies (Nevalainen et al, 2005), human biospecimens and mice deficient in specific sPLA2 isoforms was an overlapping pro-inflammatory contribution from individual sPLA2 isoforms to inflammatory arthritis.

Following this discovery he proposed that this, as well as several other conditions, were due to diets that were deficient in specific factors that he called "vitamines," later called vitamins.

Here, we investigate response to radiotherapy fraction size using CHO cell lines deficient in specific DNA repair pathways in response to radiation induced DNA double strand breaks (DSB).

To assess the role of NF-κB proteins in TEL-JAK2-induced leukemogenesis, we bred EμSRα-TEL-JAK2 mice with mice deficient for specific NF-κB genes.

Since mice deficient in specific immunity exhibit similar initial dynamics as wild-type mice it is generally viewed that the initial control of parasite is due to either limitation of resources (RBC) or innate immune responses.

However, the role of these receptors has been mostly based on in vitro examination in transfected cells; studies using inhibitors or animals deficient for specific receptors have indicated that these receptors are dispensable [2] [7].

Here we describe an application of in vivo optical imaging methods to study Aβ transport across the BBB in wild-type or animals deficient in specific efflux transporters.

Finally, there may be tumors deficient in specific repair pathways, for which inhibition of mTORC2 would lead to cell death (Fig  2).

Consequently, mice deficient in specific Atg genes produce higher levels of cytokines and have been shown to be more susceptible to certain inflammatory diseases.

Nonetheless, since the molecular understanding of cold perception by the peripheral nerves has increased recently with the use of mice deficient for specific ion channels underlying cold excitability, we evaluated the neurotoxic effects of oxaliplatin in mice.