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Skin penetrations tests in barrier deficient skin showed that nanogel-peptide conjugates enhance the penetration of m-THPC in the viable skin layers efficiently.
Indeed, the phenotype induced by Ets1 transgene expression is similar to that seen in the adult skin of other strains of mice reported to develop barrier defects (e.g., transglutaminase-1 deficient skin or matriptase over-expressing skin) [52], [53].
Procollagen I was reduced in SOD2 deficient skin compared with control skin.
Kopan and co-workers attributed the anti-tumorigenic action of TSLP in Notch deficient skin mainly to CD4+ T cells.
DOI: http://dx.doi.org/10.7554/eLife.01888.008 Since tumour resistance of Notch deficient skin is attributable mainly to CD4+ T cells (Demehri et al., 2012), we examined the effect of intraperitoneal injections of blocking CD4 antibodies.
In Notch1 deficient mice, the skin is hyper-proliferative and it aberrantly expresses differentiation markers (Rangarajan et al., 2001), while in Notch1/Notch2 deficient skin, the spinous layer is largely absent (Moriyama et al., 2008).
Similar(53)
eCollection 2017 Oct. Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.
The multiple protecting and barrier-supporting properties of the creamy, white biofilm vernix caseosa (VC) before and after birth suggest that a VC biomimetic could be an innovative barrier cream for barrier-deficient skin.
It was highly abundant in C7-deficient skin.
Thus, together, these data demonstrate enhanced pro-lymphangiogenic macrophage proximity to CCL2-expressing lymphatic vessels in uninflamed ACKR2-deficient skin.
The reduced lymphatic vessel density apparent in CCR2-deficient skin is also apparent in adult and newly weaned mice.
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