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Excessive secretion of thyroxine in the body is known as hyperthyroidism, and the deficient secretion of it is called hypothyroidism.
Endocrine disorders such as deficient secretion of the hormone progesterone may cause poor development of the decidua (the mucal lining of the uterus) or an abnormally irritable uterus and may thus sometimes result in miscarriage.
A deficient secretion of IL-12 was also reported for circulating DC from HCV patients ex-vivo [6], [16].
When cultured pituitary tumor cells expressing membrane PAM were made copper deficient, secretion of PHM increased and endocytic degradation of PAM decreased [ 32].
Hyperinsulinism increases renal sodium absorption and sympathetic tone [ 39], which combines with altered vasodilatation, which in turn is a secondary effect of nitric oxide deficient secretion by the vascular endothelium [ 40].
Impaired proinflammatory cytokine production without any reduction in cytokine mRNA levels in tnc− / − cells led us to investigate whether tnc− / − BMDMs exhibit abnormal intracellular cytokine levels as a consequence of deficient secretion.
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The defective chloride channel causes abnormal chloride transport through epithelial cells leading to deficient fluid secretion and thickening of secretions not only in the pancreas but also in the respiratory airways, kidneys and intestine [ 138].
Deficient insulin secretion often results in glucose intolerance.
This coupled with deficient insulin secretion suggestive of deteriorating β-cell function underlies the development of GDM [17].
These observations suggest that deficient incretin secretion may play a critical role in the pathogenesis of type 2 diabetes.
Type 2 diabetes is a common complex disease characterised by deficient insulin secretion and decreased insulin sensitivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com