That is, stabilization of the DDB2 and XPC repair proteins as well as the checkpoint protein p21 allowed Cul4a-deficient cells to resolve UV-induced DNA damage more efficiently than their Cul4a-proficient counterparts.
Further studies using conditional tissue-specific RPTOR and RICTOR deficient mice may help resolve the issue with respect to the relative contributions of mTORC1 versus mTORC2 signaling and fibrogenesis in an in vivo setting.
The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.
We evaluated the absolute role of T and B cells in the generation of protection against pulmonary C. neoformans infection, and found that B-cell deficient mice were able to resolve the acute infection with C. neoformans strain H99γ and were protected against a second pulmonary challenge with wild-type cryptococci.
More importantly, we here show that both aged and CD8-deficient non-human primates also resolve viral infection and fail to exhibit clinical symptoms of WNV disease when infected in a manner similar to the natural course of infection with a high dose of the virus.
It appears likely that (MSH2/ SENP6) deficient cells are incapable of resolving the genomic lesions induced by PARP-inhibition, with apoptosis becoming a preferred response.
The IR discipline that has dominated policymaking is only one possible lens, and often a deficient one, for defining, preventing, or resolving contemporary conflicts wrapped in identity politics.
Consistent with this model, mice deficient in inducible nitric oxide synthase resolved genital C. trachomatis infections as well as normal mice [ 47].
When transduced with Ad-control, control hepatocytes are able to resolve ER stress, whereas hepatocytes deficient in Lrh-1 cannot.
This tachypnea is partially resolved in animals that are deficient in IFN-γ [ 29], suggesting that the inflammatory response causes the increased respiratory rate following RSV infection.
My project for the season is to measure nutrient levels within the vegetative growth of the bine and determine what nutrients the hops are deficient or overly-sufficient in and how to resolve the issue.
