The lack of Ca(2+) influx is not due to deficient regulation of Ca(2+) stores or expression of several genes implicated in controlling Ca(2+) entry in lymphocytes (kcna3/Kv1.3, kcnn4/IKCa1, trpc1, trpc3, trpv6, stim1).
This result points to a deficient regulation of acetyl-CoA carboxylase activity.
Deficient regulation of basal apoptosis, or its perturbation, can result in impaired development and/or disease states including cancer.
Under such circumstances, deficient regulation of emotion and lacking ability to take others perspectives are additive.
An intriguing possibility is that the effect of inherited genetic risk variants leading to deficient regulation of IL-2 signalling are manifested in the increased production of IL-21 by Tfh cells.
This alteration at the vacuole has been implicated in deficient regulation of intracellular L-arginine levels, with btn1-Δ cells showing a lower ability to transport this amino acid into isolated vacuoles in vitro (Kim et al., 2003).
Hallmarks of T-cell pathology such as deficient regulation of T cells, memory T-cell expansion, persistent T-cell activation as well as T-cell polarization are dealt with; subsequently, T cell-driven granuloma and tertiary lymphoid organ (TLO) formation is discussed.
Turner also blamed a "woefully" deficient international regulation regime regarding how much capital banks should hold.
PD is an anxiety disorder characterised by deficient physiological regulation as measured by heart rate variability (HRV), and reduced HRV, PD and insomnia have all been related to impaired inhibitory ability.
Pathology can result if there is excessive activation, deficient down-regulation or both.
Overall, our findings are consistent with recent research evidence and theoretical accounts of BD which emphasize deficient emotion regulation in the pathophysiology of the disorder 3, 4, but suggest important differences between BD-I and BD-II in this process.
