Sentence examples for deficient recipient from inspiring English sources

To examine if self-peptide/MHCII recognition plays a role in the increased CD44 expression on Rasgrp1 Anaef naïve CD4+ T cells, we adoptively transferred a mixture of wild-type and Rasgrp1 Anaef splenocytes into wild-type or MHCII(H2-Aa)–deficient recipient mice.

This Cre-LoxP system uses the reverse approach of rendering donor cells vesiculation deficient; recipient cells that do not take up EVs are marked with DsRed (i.e., unrecombined reporter) and serve as an internal control for eGFP-expressing recipient cells that have taken up EVs.

In a recent study, adoptive transfer of bone marrow-derived mast cells from SHIP-1−/− mice enhanced OVA allergen induced inflammatory response in mast cell deficient recipients [16].

Indeed, CD28SA induced hardly any proliferation of conventional or regulatory CD4 T-cells in IL-2 deficient recipients, demonstrating the requirement for paracrine IL-2 in the CD28SA-driven expansion of both subsets (Fig. 3B).

In addition, by using a model of carotid artery-to-carotid artery interposition grafting in which p55 TNFR deficient (but ApoE sufficient) carotid arteries were grafted into ApoE deficient recipients, it was shown that arterial wall (i.e. smooth muscle and endothelial cell) p55 TNFR expression is pro-atherogenic [11].

While non-transferred Rag1 deficient recipients and recipients of Th17 cells rapidly died, Th1 recipients survived significantly longer than their counterparts.

In contrast, pre-immunocompetence systemic chimerism achieved in NK cell deficient recipients survives long after development of the recipient's immune system.

The DAZL-deficient recipient rat line also expresses EGFP from its transgene, but at relatively low levels [17].

Transduced and EGFP+-sorted BM cells were transplanted via intravenous injection into the sub-lethally irradiated Rag2-deficient recipient mice.

The transfer of OT-1 CD8+ T cells to lymphopenic hosts (Rag1-deficient recipient mice) results in a relatively rapid proliferation of transferred CD8+ T cells in the absence of antigen.

Along these lines, CD8+ T cells from L. casei- treated but unsensitized mice have a reduced capacity to generate a CHS response, as demonstrated in the CD8 transfer model into T cell-deficient recipient although the same frequency of hapten-specific IFNγ producing cells were generated in the recipients (not shown).