Myocardial Fatty Acid Oxidation Rates Remain Elevated in Ob/Ob Mice Despite Reversal of Obesity and Diabetes by Caloric Restriction Crystal Sloan, Joseph Tuinei, E. Dale Abel University of Utah, Salt Lake City, UT, USA Rationale: Leptin deficient ob/ob mice are commonly used to study the effects of obesity and insulin resistance on myocardial substrate metabolism.
The context of the cutback is unclear, the rationale behind the decision is deficient, and the manager does not engage the employees in how the challenge can be solved.
These findings provide the rationale for evaluating PD in children with Ink4a-ARF deficient gliomas.
The rationale was to increase potentially pathologic kinematics in PCL deficient knee joints.
Indeed, this has been our rationale to establish a modal system that mimics folate deficiency based on folate-deficient medium rather than antifolate drugs, and mimics more accurately the gene nutrition interactions early in cancer development.
The rationale behind investigating GSTs is that patients with null or deficient GST function may experience decreased platin detoxification and an increased sensitivity to cisplatin, possibly as a result of increased active cisplatin concentrations.
In line with this rationale, preclinical investigations using selective iNOS inhibitors or iNOS-deficient mice yielded promising results [ 27, 28].
In the following introduction, we first describe these two numerical systems and then portray the rationale behind the method used to explore whether DD adults are deficient in one or both of these systems.
The recent development of ACP xenotransplants in immune deficient mice [ 24] will enable pre-clinical testing of these rationally selected targeted therapies, providing further rationale for small studies on efficacy in augmenting surgery and radiation or in treating recurrent ACP.
The biological rationale for the benefit of BPs only for postmenopausal patients lies in the estrogen-deficient BM microenvironment, which may lead to bone loss by increased osteoclast activity.
Although many of these models are deficient in functions related to lymphocytes or clearance of apoptotic cells, there are others in which there is no apparent rationale for the development of a lupus-like disease.
