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Chmielewski et al. showed that perturbation training of ACL-deficient potential copers improved knee stiffness during gait, defined as knee flexion and co-contraction index.
All of these suggested adult MSCs had a deficient differentiation potential under mechanical strain.
Xist-deficient iPSCs exhibit increased expression of some X-linked oncogenes, abnormal growth rates and deficient differentiation potential relative to normal iPSCs.
For epitope mapping, the purified His-tagged GRASP65 full-length protein and various phosphorylation deficient mutants (potential phosphorylation sites mutated to alanines) were incubated with interphase cytosol or mitotic cytosol (buffers were used as negative control) at 37°C for 1 h and purified with Ni-NTA beads.
The neural mechanisms underlying deficient-evoked potential habituation in migraineurs remain unclear.
The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn.
The ERBB3- LPs in the human mammary gland are somewhat unusual since they have an intermediate phenotype between luminal and basal cells, but appear to be deficient in growth potential.
Studies on the involvement of the blood brain-barriers in AD disease were primarily focused on the (increased) permeability of the endothelial BBB barrier and the potential deficient clearance of (excess) Aß peptides across it [ 9].
Our study here pointed out that mechanical strain induced much more ROS in adult MSCs, which is at least one of the main causes of the deficient osteogenic differentiation potential of adult MSCs as ROS blocker NAC partially rescues the defect.
Our work provides a novel approach to investigate how post-translational modifications of enzymes regulate metabolism and could have important implications for understanding the metabolic transformation of FH-deficient cancers with potential clinical applications.
Mesangioblasts injected into muscles of α-sarcoglycan-null mice and dystrophin-deficient dogs show potential for gene delivery (Refs 108, 109).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com