Research into these processes is escalating and deficient pattern separation is being implicated in a wide array of genetic disorders as well as in neurocognitive aging.
Since the DAXX-deficient deposition pattern of H3.3 is not currently known, it is possible that HIRA-containing or other chromatin assembly complexes drive the deposition of H3.3 into aberrant genomic loci in the absence of DAXX, and in turn, alter the epigenetic profile of H3K9me3.
Under Cu- and Mn-deficient conditions, the expression patterns of ZmZIP genes showed no obvious change (Additional file 3).
This revealed that MMR-deficient tumors have similar patterns of mutations to those seen in egg and sperm cells.
Embryonic stem cells deficient in Shb showed altered patterns of differentiation in both mesodermal and endodermal lineages [11], [12], [14], [15].
Paget's disease usually presents with increased activity of radiotracer uptake 16; however OS secondary to Paget's disease often has a photon-deficient pattern 17.
After comparing gene expression patterns of BRCA1-deficient mouse mammary tumors with BRCA1-proficient control tumors, we noted that Ezh2 expression was particularly high in BRCA1-deficient tumors.
Juvenile social interaction has also been shown to be altered in Shank3-deficient animals, even if the patterns of reduced social parameters were not identical in the two cohorts examined (Yang et al., 2012).
Having demonstrated specific and similar alterations between Hdac1- and Hdac2-deficient enteroids, we then determined global patterns of RNA expression by RNA-Seq, selecting log2 > 1 and log2 < 1 Hdac1 or Hdac2 specific genes with DESeq adjusted p-value ≤ 0.05.
The phenotypes of kleisin-deficient mice and the published localization patterns of mammalian kleisins suggest that the models established for C. elegans will apply to mammals.
