Sentence examples for deficient maturation from inspiring English sources

Deficient maturation or impaired clearance of autophagosomes might affect the degradation of their cargo, which could lead to cell damage and neurodegeneration.

The number of red puncta per cell was significantly higher than the number of yellow puncta per cell, suggesting no deficient maturation of autophagosomes into autolysosomes in the stressed cultures.

Data accumulated from studies of loss-of-function of various ESCRT genes in a wide range of cell types, suggest that these defects result in deficient maturation of autophagosomes or in their inability to fuse with lysosomes and endosomes.

We additionally show that the defect in NK maturation is the consequence of deficient maturational cues provided by bone marrow stromal cells.

We also show that the defect in NK maturation is the consequence of deficient maturational cues provided by bone marrow stromal cells.

Beclin1, again, is likely the target responsible for the deficient autophagosome maturation in PLP2-TM expressing cells, given its involvement in the UVRAG-containing PI3K complex that controls fusion between autophagosmes and lysosomes (Kang et al., 2011; Liang et al., 2008).

Thus, the defect of nursing ability of the nm23-M1−/− females seems to be caused by a deficient terminal maturation of the lactiferous duct, resulting in milk accumulation in the duct and failure in final milk ejection.

We provide evidence showing that the growth retardation of the virgin gland is connected to abnormal proliferation and apoptosis in the terminal end buds, and we discuss some of our hypothesis to explain the deficient final maturation of the lactiferous duct in the mutant nipples.

Both situations lead to improper modulation of MeCP2-regulated pathways and result in deficient neuronal maturation.

Therapy naïve patients exhibit deficient DC maturation upon LPS stimulation, which is partially restored following antiretroviral treatment.

By contrast, placentas from mild or severe ICP exhibited fewer and smaller blood vessels in each villus, indicating disturbed placental vascular formation and deficient vascular maturation.