TLR2-deficient macrophages demonstrated marked impairment in SE-induced TNF, particularly at lower concentrations of SE tested (104 106 CFU/ml; Fig. 3B).
Leptin-deficient mice exhibit marked obesity, hyperphagia, insulin resistance, hypothermia and increased food efficiency [40], whereas iNOS knockout mice are resistant to diet-induced obesity, showing reduced epididymal fat pads and increased body temperature [26], [33].
NPC1-deficient brains are marked by neuronal lossand severe neurological symptoms.
CD148-deficient platelets exhibited marked impairment in response to the GPVI-specific agonist CRP.
Strikingly, LC3-deficient cells showed marked reduction in tumor volume and weight gain compared with control shRNA bearing MDA-MB-231 cells in nude mice xenograft model.
As a matter of fact, CD151-deficient mice displayed marked, although not quantified, albuminuria and survived for at least 5 months.
For example, one recent report demonstrated that telomerase-deficient mice have marked metabolic abnormalities owing to downregulated expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha and beta (PGC-1α and PGC-1β) (Sahin et al., 2011).
JUN-deficient fibroblasts have marked proliferative defects in vitro (Schreiber et al. 1999; Wisdom et al. 1999), and proliferation of JUN-deficient hepatocytes is severely impaired during liver regeneration in vivo (Bakiri et al. 2000; Behrens et al. 2002; Schreiber et al. 1999).
TLR8 deficient mice (B6.TLR8−/−) and particularly double TLR8/9-deficient mice (B6.TLR8/9−/−) displayed marked induction of TLR7, which was associated with more severe disease.
Soifer adds that some are more worried about people hearing their urine hitting the toilet bowl or water than they are about being noticed and marked as deficient males.
Mouse embryonic fibroblast cells that were isolated from IKKβ deficient embryos showed a marked reduction in TNFα- and interleukin-1alpha-induced NF-κB activity, as measured by EMSA and by effects on IκB degradation.
