These results indicate that impaired IgG production in CX3CR1−/− or CX3CL1−/− mice was related to deficient interaction between surface CX3CR1 and CX3CL1, but do not allow to establish whether this effect is attributable to direct ( B cell related) or indirect (accessory cell related) mechanisms.
Potassium also engages in long, weak, electron-deficient interactions with the zinc-bound ethyl ligands (in the range of K Cα lengths 3.140 2)–3.3896(17) Å).
Using the partition interaction test, with ovariectomized C3H female mice as the stimulus, this group reported that Fmr1 knockout mice exhibited deficient social interaction and impaired social preference [17].
The importance of TEADs in the function of YAP was nicely demonstrated by a mouse model with knock-in of a mutant YAP deficient in interaction with TEAD.
Furthermore, Rad51 mutants, originally isolated as Rad52-interaction deficient mutants [61], also appeared defective for the interaction with Srs2, suggesting that these proteins compete for the same interaction region on Rad51 [29].
These PP1-binding deficient mutants retained interactions with endogenous actin (Fig. 7B).
Autism spectrum disorders (ASDs; MIM 209850) are acknowledged to be among the most heritable neurodevelopmental disorders with onset prior to age 3, which characterized by impaired reciprocal social interactions, deficient communication, restricted interests and stereotyped activity patterns (American Psychiatric Association, 2000).
(19) Although it is possible to promote maturation using compounds that bind to NBD1,(20) it is possible that they may not stabilize CFTR because they are still deficient in NBD1 TMD2 interactions because of the lack of Phe508 at this critical interface.
Repressed ClpB-E432A is deficient in DnaK interaction and cannot be activated by its Hsp70 partner.
