Crosses between TNFtg and IL-1 deficient mice yielded insight into IL-1-dependent elements and it was convincingly demonstrated that TNF drives inflammation.
Additionally, because deficits in inhibitory control are related to both PTSD and TBI, understanding the specific context in which inhibitory control is deficient may lend insight into dysfunctional neural mechanisms that are associated with the specific diagnoses.
We developed a mouse model mimicking human BRCA1-deficient breast cancer to gain insight into the molecular progression of BRCA1-deficient tumors and to test putative therapies [ 12].
Looking at the effect on Type I IFN production in CD8+ T cells with deficient SOCE may provide additional insight into the cytotoxicity of these cells, since IFNa has been implicated in maintaining the survival of memory CD8+ cells, which has direct implications for sustained antitumour immunity.
Because the function of BOK has not yet been clearly defined to date, analysis of these doubly deficient mice may aid in providing insight into whether BOK functions in a BAX/BAK-like pro-apoptotic manner.
The establishment of a mouse model is of great importance, as the availability of diverse immune-deficient mouse models could deliver more insight into immunological processes of radiation nephropathy in prospective studies.
Results Here, the authors examined the osteoblastic differentiation of MMP-2-deficient cells in vitro to investigate the secondary molecular changes that occur in MMP-2-deficient osteoblasts, with the aim of gaining insight into the overall molecular features of MMP-2 deficiency.
To gain mechanistic insight into causes of functionally deficient cardiac beating areas, cardiomyocytes were isolated from embryoid bodies after knockdown of AK1, AK2 and AK5 isoforms.
Identification of these modifier genes and further comparative functional analysis utilizing mice deficient in Hif1α and Hif2α will provide insight into the precise molecular mechanisms leading to the development of VHL-associated pancreatic disease.
Further studies on the Col4a5 genetic-deficient AS animal models will provide new insight into mechanism research, diagnosis, and target therapy of AS in human.
Because brain samples from the affected individuals described by Simpson et al. were not available for analysis of brain gangliosides and pathology, mice deficient in ganglioside glycosyltransferases are important for gaining insight into the potential mechanisms underlying this disorder.
