We also asked whether the consistent difference in weight between Ate1-deficient and Ate1-containing mice on a standard ad libitum diet (Fig. 4A C) could be reduced by an energy-rich, high-fat diet (HFD).
IGF2 is an early growth factor expressed at the two-cell stage in the mouse embryo[ 61], and mice deficient in IGF2 have reduced birth weight [ 58].
Previous work has revealed that in a fibroblast cell line derived from a Fanconi anaemia patient deficient in SLX4, the high molecular weight complex of ERCC1 XPF is absent (Stoepker et al, 2011b).
While one would expect differing phenotypes, increases in weight gain and adiposity, glucose intolerance, and insulin insensitivity, are observed in both AR deficient and ERα deficient mice [43], [44], [45], [46].
IL-27R-deficient mice did not have significant difference in lung viral burdens or in weight loss, when compared with WT mice after influenza infection (supplementary Fig 5).
Studies reporting a difference in weight gain between analgesic-treated and unmedicated calves after dehorning are deficient in the published literature.
For example, recent studies have shown that mice deficient in leptin or the leptin receptor undergo extreme weight gain but exhibit no changes in osteoarthritis [ 76].
Diets deficient in methionine and choline have been proven to lead to weight loss in rodent models studied earlier.
Animals with a diet deficient in zinc require twice as much food in order to attain the same weight gain as animals given sufficient zinc.
When methionine is deficient in the diet, there is an immediate decrease in food intake, and severe weight loss [ 27].
Mice that are deficient in this isoenzyme exhibit delayed growth with a 30-40% decrease in body weight at 1 2 weeks after birth [ 35].
