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Neglected children, by far the majority of children maltreated, experience an environment most deficient in cognitive stimulation and language exchange.
Consistent with exhaustion, PD-1hiTIM-3+ T cells are antigen-experienced cells that are deficient in producing cytokines following stimulation through the TCR.
Desensitization, an essential homeostatic response to excessive or continued beta-adrenoceptor (betaAR) stimulation, is deficient in immature cells.
In conclusion, adrenal cortisol secretion following dynamic stimulation is deficient in a substantial proportion of brain-dead patients.
In conclusion, adrenal cortisol secretion following dynamic stimulation is deficient in a subset of head injury patients; this condition is associated with vasopressor dependency.
Without stimulation, BMDMs deficient in caspase-8, RIPK3, or both caspase-8 and RIPK3 displayed increased LDH activity, indicating an increase in cell death.
In conclusion, adrenal cortisol secretion after dynamic stimulation is deficient in about two-thirds of critically ill patients; this disorder is associated with higher IL-1 and IL-12p70 levels.
As predicted, the lipin-1α mutant that was deficient in nuclear localization also showed a defect in stimulation of MEF2 transcription (Figs. 7B-7D).
We found that CD14 knockout macrophages were almost completely deficient in inflammatory responses to PG-PS stimulation in vitro.
To assess the role of miRNAs in hepatic ER stress, we first investigated the expression levels of ER stress markers after bile acid stimulation in hepatocytes deficient in the miRNA-processing enzyme Dicer.
Some ligands for EGFR, such as amphiregulin, are strongly matrix binding and may act as pseudotethered ligands, hence presentation of EGF tethered to PEG hydrogels may mimic a mode of natural stimulation that is deficient in synthetic matrix.
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