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"Data is deficient for a quarter of them, which means we don't know whether they are threatened with extinction or not and about half of all amphibian populations are in decline.
Mutant flies genetically deficient for a functional Hippo (Hpo) [1]-[5], Savvador (Sav) [6],[7] or Warts (Wts) [8],[9] exhibited similar phenotypes consisting of robust tissue overgrowth, enhanced cell proliferation and suppressed apoptosis.
Cabinet Office minister Francis Maude, who has oversight of Universal Credit as part of his civil service reform role, said it was a "very hard-hitting" and "useful" report which highlighted wider problems in Whitehall: "We are not that good at financial control... but also project management has been deficient for a long time".
These mice deficient for a chemokine receptor are fully susceptible to ECM but have a strong reduction in monocyte (50%) and neutrophil (100%) numbers in their brains at the time of ECM when compared to WT mice [44].
Due to the close proximity (<1 kb) of the HSPB2 gene to CRYAB and the sharing of promoter elements [33], the αB-crystallin knockout mice are also deficient for a second sHsp, HspB2.
However, as a single cell divides to form a colony, cells randomly lose these plasmids, leaving some of the cells deficient for a particular metabolite.
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Mice genetically deficient for an alternative BAFF receptor, TACI (TNFRSF13B), are not able to generate plasmablasts in response to TI antigens [ 37, 38].
Surprisingly, DCs deficient for any TLR showed a normal response to E. muris infection (Figure S7A and B).
Human colorectal adenocarcinoma HCT116 is a poorly differentiated, growth factor-insensitive cell line deficient for hMLH1, a homologue of the bacterial Mut L protein and crucial component of DNA mismatch repair.
Of interest, the body weight profile of mice with VEGFR2 blockade by DC101 treatment in this study is strikingly similar to data from mice genetically deficient for PlGF, a selective ligand for VEGFR1 [22].
Mice deficient for VAC14, a scaffolding protein required for PIP2 biosynthesis and linked to human neuropathies, show increased postsynaptic function due to altered AMPA receptor trafficking.
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CEO of Professional Science Editing for Scientists @ prosciediting.com