Sentence examples for deficient feedback from inspiring English sources

These results are significant in that neuroimaging studies in humans indicate that deficient feedback monitoring in the cortex is associated with learning deficits due to D2 receptor polymorphisms [ 25, 26].

For instance, strains with deficient feedback inhibition of aspartate kinase accumulate up to 40 times more threonine than the wild-type strain, without apparent loss of cell viability [ 50].

So, alterations in the intrinsic circuitry of the amygdala and anterior cingulate cortex may result in altered connectivity, deficient cingulate feedback regulation on amygdala function and abnormal processing of emotion-related stimuli in depression [11], [12].

Reprogramming is accomplished by overexpressing a negative feedback deficient heat-shock response transcription factor before and during overexpression of the protein-of-interest.

The discovery that at least one mutant protein was deficient for PEP feedback inhibition opens a new aspect for research on the pathomechanism, as impaired redox metabolism has been reported as feature of TPI deficiency (Ahmed et al., 2003).

The results of several (pre clinical studies show that haptic feedback is deficient in laparoscopic surgery [3, 4, 5].

These models of SS include mice deficient for NF-κB feedback regulation (C57BL/6. IκBα M/M ) and mice transgenic for Baff[ 7].

The combination of genetic tools and metabolomics has also been used to identify a previously unrecognized uridine monophosphate (UMP) degradation pathway in E. coli strains that are deficient in a negative feedback regulator of pyrimidine homeostasis 33.

The resulting alteration in RyR gating properties and SR Ca2+ handling may, however, amplify cell damage in a positive feedback, as deficient Ca2+ transfer from RyR to adjacent mitochondria further increases oxidative damage (impairing NADPH regeneration) and ultimately leads to inefficient energy production.

Moreover, we found that the requirement for Doa10 function increases in sterol esterification-deficient cells, indicating that feedback regulation of Erg1 and sterol esterification are redundant pathways preventing accumulation of sterol intermediates.

Because this latter receptor is required for feedback inhibition, a deficient expression might contribute to humoral autoimmune responses.