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Only a small minority of people suffer from diseases of or deficient development of the genitalia or that part of the neurophysiology governing sexual response.
Many children with DD show a deficient development of such a mental number line.
This association is thought to be due to the collapse of the primitive fetal ventricular system (brought about by the loss of cerebrospinal fluid through the spinal defect), which prevents the rhombencephalic vesicle (from which the brainstem, fourth ventricle, and cerebellum are derived) from expanding and results in deficient development of the posterior fossa and herniation [38].
Taken together, our results show that both deficient development of T cells in the thymus and an abnormal antigen specific response in the periphery contribute to the phenotype of peripheral T cells in Foxn1Δ/Δ mice.
The observed Cho elevation may thus be interpreted as reflecting deficient development of the neurons.
Problems with learning long behavioural sequences may ultimately lead to deficient development of verbally governed behaviour and self control.
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Results from recently completed multicentre trials indicate that coformulated AS+CD can cause serious haemolysis in children who are G6PD deficient so further development of this drug combination has been halted.
Future biomechanical studies must show, whether there is a direct influence between kinematic changes in PCL deficient knees and development of osteoarthritis.
IL-1β-deficient mice showed development of OA.
Interestingly, adiponectin was able to stimulate AMPK activity in podocytes, mesangial cells, and glomerular endothelial cells [ 39], and adiponectin-deficient mice showed development of albuminuria together with decreased AMPK activity in podocytes [ 38].
Such a combination of these processes already has been widely reported in studies of cancer, showing, for example, that methyl-deficient diets induce development of liver tumors (i.e., hepatocarcinogenesis) associated with global DNA hypomethylation and promoter hypermethylation at specific genes (Ehrlich 2005; Pogribny and Rusyn 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com