Sentence examples for deficient degradation from inspiring English sources

Furthermore, expression of the relatively insoluble subunits of simple epithelial keratins carries the risk of protein aggregation induced cellular disease [30]in the event of mutation, imbalance of subunit expression, chemical induced aggregation or deficient degradation [31].

The deficient degradation of PGs may accumulate limited degradation products within the cell with harmful effects to the organism.

In addition, deficient degradation of autophagic substrates in cells in GD can lead to an increased risk of Parkinson disease.

This may represent excess free Pen-2 resulting from deficient degradation of the mutants, perhaps due to their altered cellular localization.

It is metabolised in the liver, producing α-androstenol and β-androstenol [ 6, 7], and deficient degradation may lead to the accumulation of androstenone in adipose tissue.

Thirdly, presence of capsule may cause deficient binding, degradation or masking of complement components [ 9].

Deficient lysosomal degradation, but not impaired autophagy, of BACE1 could cause BACE1 accumulation in presynaptic endosomes.

It might be expected that deficient PI 3,4,5 P3 degradation by PTEN would lead to the subsequent accumulation of PI 3,4,5 P3 and p-Akt hyperactivation.

As indicated above, sIBM is accompanied by degenerative protein accumulations, and deficient protein degradation pathways (both proteasomal and lysosomal) and one accumulated protein candidate might be HLA class I [ 36].

However, E6's oncogenic activities cannot be explained solely by its effects on p53, and mutants deficient for degradation of p53 can still immortalize mammary epithelial cells, suggesting that interactions with cellular factors other than p53 are necessary for cancer development [ 11].

When growing in a cobalt-deficient medium, degradation rate and growth rate were significantly reduced [ 35].