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ErbB2-deficient conditional mutant adult mice were viable and displayed no overt phenotype, but physiological analysis revealed a phenotype consistent with dilated cardiomyopathy [14, 15].
ErbB2-deficient conditional mutant mice were viable; however, physiological analysis revealed the onset of multiple independent parameters of dilated cardiomyopathy.
Analysis of Shh−/−, Gli3−/−, and Smo-deficient (conditional, T lineage) thymi has shown that Hh signaling is a positive regulator of the early stages of thymocyte development, controlling homeostasis of DN progenitors and differentiation from DN1 to DN2.
Polyethyleneimine labeling of fetal kidneys revealed anionic sites along both laminae rarae of the GBM that became most prominent along the subepithelial aspect at maturity; labeling was greatly reduced along the subepithelial aspect in agrin-deficient and conditional knockout mice.
A second protocol was to take advantage of the nephron-deficient Lim1 conditional mutant kidneys to identify nephron-specific genes of different developmental stages [ 20].
Studying IR-injury and neurotoxicity in RIPK3-deficient or conditional RIPK1 knockout mice will be required to identify the precise role of RIPK1 targeting and necroptosis.
GSE47851 is from a study that used Gata3 conditional deficient mice [ 12].
Compensation between pannexins and/or connexins able to form hemichannels may exist in classical deficient mice and conditional Panx-1 mice would be useful.
In opposition to CD45, Csk negatively regulates Lck and Fyn, as shown by their 2-5-fold increased basal catalytic activities in Csk-conditional deficient thymocytes [24].
To examine the physiological functions of OGR1, we generated conditional OGR1 deficient mice by homologous recombination.
A lack of GP130 in T cell specific conditional gp130 deficient mice models causes the activation of Th2 and regulatory T cell pathways [70].
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