Sentence examples similar to deficient car from inspiring English sources
This work proposes to address these three requirements through the development of multidrug-resistant T cell receptor αβ-deficient CAR T cells.
It has also been shown that a cytoplasmic domain-deficient CAR containing the FcεRIγ chain can activate T cells via heterodimerization with endogenous CD3ζ [ 11].
The first clinical trial evaluating a tropism-modified Ad vector containing a genetically modified fiber protein, allowing Ad transduction of cancer cells deficient in CAR (as wt SNc neurons have herein been shown) has recently been completed and suggests that this paradigm is safe for use in patients [38], and the development of other such trials is continuing [39].
It was reported that adenoviral aggregates precipitated by calcium phosphate enhanced gene transfer to airway epithelia deficient in CAR expression [ 35].
Fasbender et al. [ 35] found that adenoviral aggregates precipitated by calcium phosphate could enhance gene transfer into airway epithelia deficient in CAR expression.
TCPOBOP in CAR deficient mice lowered expression of all measured genes.
The present study showed that PTD.AdeGFP significantly improved gene transfer to multiple cell types deficient in expression of CAR.
Therefore, in order to examine whether the pK peptides incorporated into the triple pIX mosaic Ad vector had similar targeting activity to HSPGs, we performed cell binding and inhibition assays with CAR-deficient (low level of CAR) AU-565 cells in the presence or absence of heparin or soluble CAR (sCAR) protein.
Ad5Luc1-CK gene delivery to CAR-deficient cells was augmented up to 30-fold versus the Ad5 control vector, and correlated with increased cell surface binding.
However, a previous publication of our group showed that the pK-induced cell binding enhancement correlates with the transduction enhancement in several CAR-deficient cell lines (including AU-565 cell line) [13].
