Sixty deficient arrays for solid cancer experiments and 41 deficient arrays for haemic cancer experiments are excluded, which is about 1% of the data.
Due to duplicated arrays in different experiments (from one cancer entity) and several deficient arrays, the set of arrays used in the analysis is smaller than all available arrays.
Barash et al. 2005 [ 92] studied CSRP3 knockout mice and found that deficient mice displayed an array of skeletal muscle defects such as shorter sarcomere length and muscle atrophy.
To investigate the effect of stable overexpression of Large on specific glycans, we have established an array of glycosylation deficient CHO cell lines (Pro5, Lec1, Lec2, and Lec8), in which mouse Large tagged with a MYC epitope was stably expressed and termed as Pro5-LG, Lec1-LG, Lec2-LG, and Lec8-LG, respectively.
We characterize miR-142-deficient mice that display an array of hematological defects, including pronounced thrombocytopenia.
In conclusion, our report has identified an intricate interaction of prospective (mitochondrial and nuclear encoded) markers for the selective penetrance, progression and prognosis of PCa, and potentially a diverse array of respiratory-deficient (e.g., aging) pathologies.
In line with this hypothesis, cells that are deficient in NPC1 accumulate a wide array of lipids, including cholesterol (Fig. 1A,B) and sphingomyelin within the endocytic system (Lloyd-Evans et al., 2008).
These mice have compromised responses to an array of immune functions, including deficient germinal center formation and immunoglobulin isotype class switching, reduced delayed hypersensitivity responses, and reduced helper cell differentiation.
The p53 tumor suppressor protects against an array of different tumors and p53-deficient mice succumb to lymphomas and many different types of sarcomas [ 7].
Furthermore, AIRE-deficient mice have decreased expression of a wide array of PTAs and develop circulating autoantibodies, infertility and multi-organ lymphocytic infiltration, mostly in endocrine organs, just like in patients with APECED 161, 162, 163.
Research into these processes is escalating and deficient pattern separation is being implicated in a wide array of genetic disorders as well as in neurocognitive aging.
