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The ability of α-methyl-p-tyrosine (αMT), a potent irreversible inhibitor of TH, to selectively deplete brain DA in mice lacking the DAT provided a simple in vivo model of DA deficiency to use as a test system to analyze DA-independent actions of various compounds [12].
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One solution to these deficiencies is to use an electronic system to report disease to public health authorities.
Individuals with limb deficiencies are taught to use prosthetic replacement devices.
Having excluded promoter-dilution effects as a reason for AOX rescue of COX deficiency, we set out to use the UAS-AOX lines, in combination with different GAL4 drivers, to analyse the developmental phenotypes produced by knockdown of COX subunits, and the degree to which AOX expression is able to complement them.
These deficiencies urged the need to use the modified DISCERN version, which has been tested and used in earlier publications.
It is worth noting that there is no rank deficiency in Λ due to using of the phase rotation (see Appendix Appendix 3: Rank of the constructed code).
Rice roots exposed to Fe deficiency were used to investigate diurnal changes in expression levels of genes involved in Strategy II Fe uptake and translocation.
Instead, it is precisely this necessary deficiency that we use to better understand metrics for transcriptome assembly quality.
Using the new protein nomenclature and aiming to achieve improved clarity, we recommend that the term 'riboflavin transporter deficiency, type 2' be used to correspond to the SLC52A2 encoded RFVT2 (formerly RFT3) and 'riboflavin transporter deficiency, type 3' to correspond to the SLC52A3 encoded RFVT3 (formerly RFT2).
The mucopolysaccharidosis type VII mouse with β-glucuronidase deficiency was used to develop an alternate approach to gene therapy, in which a "universal" cell line engineered to secrete the missing enzyme is implanted directly into all recipients requiring the same enzyme replacement.
To identify the causative genetic lesion, the peripheral blood T cell deficiency was used to map the mutation in an F2 intercross to a genomic interval between 163.16 and 165.88 Mb on chromosome 2. Whole-exome sequencing of DNA from an affected mouse identified a single novel single-nucleotide variant within the interval of interest: a C to T missense mutation in exon 21 of Zfp335.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com