Exact(1)
To generate a novel mammalian model of ACDase deficiency to allow us to better study FD progression, the role of lysosomal ceramide in vivo, and evaluate experimental therapies, we introduced a single nucleotide mutation into the murine Asah1 coding sequence via genomic recombination ("knock-in").
Similar(59)
Consequently, grafting procedures are common treatments in the dental setting to correct these deficiencies and to allow for proper three-dimensional implant placement.
Identification of ADAMTS-13 deficiency is helpful to allow specific care [ 8, 9, 25– 28] of this potentially fatal disease [ 10, 15, 23, 29– 31].
The mapping of physical breakpoint positions within each deficiency strain is required to allow the deleted gene complement for that strain to be precisely defined.
The "deficiency kit" employs large deletions to allow rapid screening of the majority of the genome, with a minimum of strains and crosses.
Researchers have used genetic technology to produce a number of genetically modified murine models to overcome the many deficiencies of larger animals, particularly to allow studies of potential therapies that require large numbers of subjects.
Such a malfunction may lead to severe zinc deficiency and allow copper to reach toxic levels in membranes leading to lipid peroxidation and cell damage [ 68].
In this context, the early identification of a severe, antibody-mediated, ADAMTS13 deficiency may allow to start targeted therapies such as B-lymphocytes-depleting monoclonal antibodies.
Finding quantifiable alterations in the cerebral tissue due to maternal TH deficiency would also allow us to assess the influence of other factors such as alterations in the regulation of glycemic homeostasis, ischemia induced by respiratory deficiency, etc. that also delay brain development.
Two people who also lack these qualities are not allowing this deficiency to trammel them.
CRN, first introduced in [4, 5], is a new paradigm for wireless communication that allows spectrum deficiency to be exploited in an opportunistic manner.
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