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Substitution of a conserved cysteine (Cys) breaks one of the three disulfide bridges in the selected saposin and results in the deficiency of that individual saposin (14, 21).
Generally, perlecan is very important for developmental angiogenesis, so the deficiency of that could be largely responsible for organ failure in these embryos [ 34, 116].
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Previous work demonstrated that a deficiency of proteins that impact the actin cytoskeleton affect the number and activity of synapses, as well as memory and learning (Soderling et al, 2007).
Subsequent events, however, have shown that he was right: it was the deficiencies of that deal that led to the latest antitrust trial.
In each of us there is something unfulfilled, some ache or deficiency of character that leads us to fill a hole in the heart with the love of strangers.
It was not some deficiency of imagination that led Turing to model his computing machines on what could be achieved by a human computer.
Onset of infection is associated with deficiency of cytokines that regulate T cell homeostasis.
We have created a conditional mouse mutant with brain-restricted deficiency of PEX13 that exhibits cerebellar morphological defects.
MPS III, also referred to as Sanfilippo syndrome, is caused by a deficiency of enzymes that are needed to break down heparan sulfate.
Another potential mechanism that could link proteinuria with FGF23 levels is secondary hyperparathyroidism, induced by deficiency of vitamin D that accompanies proteinuria.
3) Properly designed testing can identify specific areas of deficiency that can be efficiently addressed by individualized tutoring and/or group classes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com