The MSI pathway involves a failure of the mismatch repair system (Aaltonen et al, 1993), which maintains genetic stability not only by repairing DNA replication errors but also by preventing chromosomal recombinations; a deficiency of mismatch repair helps cells overcome cellular crises caused by critical shortening of telomeres (Bechter et al, 2004).
Less frequent donation of blood (currently in New Zealand, individuals can donate blood up to four times per year [ 30]) or discouragement of blood donation in women at risk of iron deficiency may help to reduce their risk of developing suboptimal iron status.
Deficiency of IGF-1 could help to explain the decrease of muscle mass and the increase in fat mass that occurs in many older people.
In the increasingly complex climate of diabetes management options, confirmation (or not) of insulin deficiency should help guide treatment, education and management decisions, which will be valuable in optimizing care for any patient, but perhaps particularly for the more frail, older patient.
Zinc (Zn) is an essential micronutrient for living organisms, and understanding the molecular mechanisms of Zn deficiency may help to develop strategies to mitigate this problem.
Early recognition of G6PD deficiency can help prevent these serious complications.
In the glycogen storage diseases glycogen accumulates in muscle fibre, because of a deficiency of an enzyme that helps degrade glycogen into lactic acid for the production of energy.
Hence, community-prevention of patients developing nutritional deficiency should help improve healing rates following the onset of a wound.
Both of these classes of secretion deficiency have helped us to understand the role and mechanisms of platelet secretion on different levels.
Patients lose certain brain cells in the hypothalamus, leading to a deficiency of hypocretin, a molecule that helps regulate the sleep-wake cycle.
To help overcome the deficiency of the traditional method, a modern method for motion analysis, called PCA-based motion analysis, is proposed in this paper.
