Sentence examples for deficiency of functional from inspiring English sources

One strategy seeks to correct deficiency of functional coagulation factor IX (hemophilia B) by intramuscular (IM) administration of an adeno-associated viral (AAV) vector.

Validation of key computational predictions supports the concept that understanding the molecular complexity of insulinoma may be a valuable approach to diabetes drug discovery.Diabetes results in part from a deficiency of functional pancreatic beta cells.

Unfortunately, the osteoinductivity of microcapsules has been restricted by many factors, among which the deficiency of functional proteins is a significant priority.

This indicates that the deficiency of functional Dp427m isoform is the major cause of dilated cardiomyopathy in DMD patients, which is consistent with previous studies from DMD animal models (Ameen and Robson, 2010; Quinlan et al., 2004).

The persistence of increased S6 phosphorylation after rapamycin may suggest that the inhibition of mTORC1 activity was incomplete, though given the decreased numbers of oligodendrocyte precursors seen prior to P17 and that rapamycin can decrease expression of myelin proteins, a complete rescue may not be possible as a deficiency of functional oligodendrocytes is likely.

Bultink and colleagues, in a study designed to analyze the effect of the deficiency of functional mannose-binding lectin, found that treatment with HCQ was protective of major infections, with an adjusted OR ORR = 0.05, 95% CI = 0.01 to 0.23) very similar to that obtained in the present study [ 5].

To conclude, we observed a reduced survival in embryonic and adult myd88−/− zebrafish, most probably caused by a primary immune deficiency due to the lack of functional MyD88.

The key to this solution will ultimately come from developing a better understanding of the second major biochemical consequence of BRCA1 deficiency: the loss of functional complexes between BRCA1- and BRCA1-interacting proteins (BIPs).

In the present study, the deficiency of properdin caused functional changes in both neutrophils and CD4+ T cells that prevent the development of inflammatory processes and joint alterations.

Our findings demonstrate a consistent pattern of functional deficiency and provide further support for a helicase-dependent cellular function of RECQL4 in addition to its Nterminus-dependent role in initiation of replication, a function that may underlie the phenotype of RECQL4-linked disease.

However, the observation that a deficiency in the amount of functional MBL increases the severity of sepsis has been made repeatedly [ 27, 30].