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Deficiency means lack of activities, such as immunodeficiency, of the body organ(s).
Furthermore, the Haddon matrix enables us to identify deficiencies of activities at intervention levels and strategies to bear in mind in order to enhance the future AIDS prevention programs.
The decrease or deficiency of the activities of those antioxidative enzymes could contribute to tumorigenesis [ 52, 53].
However, the relative contribution of CGL- and CBS-mediated production of H2S in the regulation of blood pressure and the deficiency of their activities in the pathophysiology of hypertension is not yet clearly known.
Elegant biochemical dissection of the functional domains revealed that pathology results from deficiency of GGT activity and not lysyl hydroxylase activity, demonstrating that glycosylation is necessary for intracellular trafficking (43, 44).
To confirm the deficiency of RNase activity in the K833A homozygous lines (K833A lines), the response of these lines to ER stress was investigated.
Lesch Nyhan (LND) disease is an inborn error of purine metabolism which results from deficiency of the activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT).
It does not produce symptoms of hypothyroidism (deficiency of thyroid activity) in most patients, nor does the condition affect life expectancy.
The AEC were used as donor cells for cell-mediated gene therapy of CNS lesions in mice with mucopolysaccharidosis type VII (MPSVII), a lysosomal storage disorder caused by an inherited deficiency of GUSB activity.
In this study, we identify that deficiency of TLR9 activity in primary microglia blocked morphine-induced microglial apoptosis.
Deficiency of CBS activity is the most common cause of hereditary hyperhomocysteinemia [4] and over one hundred patient mutations in CBS have been described [5].
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CEO of Professional Science Editing for Scientists @ prosciediting.com