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In the Results the authors write that cardiomyocyte deficiency observed in aplnr deficient embryos could not be phenocopied by loss of apelin function.
As the dose of Pitx2c is crucial for normal left right patterning and cardiac development, we suggest that Pitx2c deficiency observed in Cited2 heterozygous hearts and embryos could explain, at least in part, the observed cardiac malformations.
The possible reason is decreased vitamin D production because of the lack of sunlight exposure, use of sunblock, or by the disease itself, like the deficiency observed in medical inpatients [10].
Various factors like duration and timing of sun exposure, amount of skin exposed, skin pigmentation, dietary and genetic factors [19, 20], have been implicated as possible reasons for the high incidence of vitamin D deficiency observed in the tropics.
Such strong overdominance would also be expected to counter the heterozygote deficiency observed in spring.
The variation of Smad7 deficiency observed in the study is likely caused by incomplete expression of Cre recombinase driven by the albumin promoter (Figure S1).
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Most of the manifestations of ariboflavinosis (a medical condition caused by riboflavin-deficiency) observed in the riboflavin-deficient rats were eliminated when the diet was supplemented with milk fermented by L. lactis pNZGBAH a strain that overproduces riboflavin during fermentation.
Furthermore, the memory deficiencies observed at 8 months coincides with the observed increase in frequency of Hirano bodies.
The structural deficiencies observed in these buildings are given.
The results are processed to explain quantitatively the structural deficiencies observed in the field.
The F.D.A. report concerns manufacturing deficiencies observed by federal health investigators during a routine inspection of the plant in April.
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