We show that the discretized PB model takes the form of a Feinberg Horn Jackson zero-deficiency network, allowing us to prove stabilization of the whole system.
A procedure is given to make this determination for any deficiency one network, no matter how intricate, so long as it satisfies certain weak structural conditions.
The following problem is considered: Given a deficiency one network, determine whether there exist rate constants for it such that the corresponding isothermal mass action differential equations admit multiple positive steady states.
A more detailed explanation of the flux minimization problem is given in Additional file 5: Appendix A. This approach has been applied to an erythrocyte model to simulate the impact of enzyme deficiencies on network performance [ 20].
In addition CoNtRol calculates the deficiency of a network and checks if a network is weakly reversible.
Aiming at the deficiency of IP network, Van Jacobson put forward Content-Centric Networking (CCN) in 2009.
Network deficiency exacerbates impairment in a mouse model of retinal degeneration.
However, if your insurance covers a service but has no one in-network to provide the service, it is possible to claim a "network deficiency" to access another provider.
The better correlation (r = 0.671) between the experimental data and the decrease of the network deficiency suggests that the approach could be a promising computational systems biology tool to aid identification of anticoagulant activities of compounds in drug discovery.
We compared the performances of two docking approaches, Autodock and Ligandfit, and found that the decrease of the network deficiency based on the predictions given by Autodock can give better correlation with the experimental data (r = 0.671) than that based on the predictions given by Ligandfit (r = 0.47).
The dimension of this subspace is the deficiency of the network, δ= d i m(D δ ).
